Oral vaccine prevents recurring UTIs for nine years
An oral vaccine in the form of a pineapple-flavoured spray prevented recurrent urinary tract infections in 53.9 per cent of clinical trial participants
By Jocelyn Solis-Moreira
9 April 2024
Bacteria found in urine
STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY
A new oral vaccine helped prevent recurring urinary tract infections (UTIs) for nearly a decade. A clinical trial showed that the pineapple-flavoured vaccine spray helped 53.9 per cent of people remain UTI-free for nine years.
UTIs are among the most common bladder infections, and they disproportionately affect women. About 40 to 60 per cent of women experience a UTI at least once in their life, and one in four are prone to repeat infections. Urinary tract infections are often treated with antibiotics. However, this incurs the risk of antibiotic resistance, making these drugs less effective with repeated use.
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As an alternative, researchers developed the MV140 vaccine, which contains four inactivated bacterial species that cause UTIs. The dissolved vaccine, sprayed under the tongue daily for three months, passes through the soft mucous membrane inside the mouth to stimulate lymphoid tissues, a component of the immune system.
The latest clinical trial, presented on 6 April at the European Association of Urology Congress in Paris, is the first to show the long-term effectiveness of the MV140 vaccine. The study authors previously reported the short-term effectiveness of the vaccine after three and six months. The researchers tracked the medical records and regularly followed up on 89 participants who received the vaccine in 2014. All participants had a history of UTIs but were UTI-free during the three-month vaccination period.
After they completed treatment with the spray, people remained infection-free for an average time of 54.7 months. More than half of the group – 54 per cent of the women and 53 per cent of the men – avoided UTIs for nine years.
